about John C. McKew, Ph.D.:
John McKew is Chief Scientific Officer of Lumos Pharma. Dr. McKew has spent the last 25 years developing novel therapeutics. He has successfully moved therapeutics through pre-clinical and into clinical development in publicly traded biotech, large pharma, government labs, and privately held biotech companies. Dr. McKew was head of research at aTyr Pharma where he led a research team discovering and advancing protein-based therapeutics for rare diseases. Dr. McKew was also the Acting Scientific Director of the National Center for Advancing Translational Science (NCATS) intramural group where he was responsible for scientific efforts ranging from high throughput screening and in vitro toxicology efforts, as well as a team of medicinal chemists. Dr. McKew’s lab focused on developing two drug discovery programs, Therapeutics for Rare and Neglected Diseases (TRND) and Bridging Interventional Development Gaps (BrIDGs) where projects are advanced using novel public/private partnerships. The team’s expertise spanned pre-clinical and IND enabling data generation to first in human and observational studies at the NIH clinical center. Several innovative therapies that were collaboratively advanced through these programs are now being commercialized by pharmaceutical companies (i.e. VTS-270 for Niemann-Pick disease). Before joining the NIH, Dr. McKew held a Director level position at Wyeth Research in Cambridge, Massachusetts. At Wyeth Research he led a variety of research initiatives including a hit-to-lead chemistry group which supported cardiovascular, musculoskeletal and metabolic disease therapeutic areas. He began his professional career at Genetics Institute, Inc., where he worked on translating novel inflammation targets into clinical candidates.
Dr. McKew is also currently an Adjunct Associate Professor at the Boston University School of Medicine. He has also served as the Chair Elect, Chair and Immediate Past Chair of the American Chemical Society’s Northeastern section. Dr. McKew also participates in multiple special emphasis panels (SEP) (NCI NeXT, CPRIT, AND NCI SBIR advisory panel) He has over 60 peer-reviewed publications and granted patents. Dr. McKew graduated from State University of New York at Stony Brook with B.S. degrees in Chemistry and Biochemistry, completed his Ph.D. in Organic Chemistry at University of California, Davis and held post-doctoral research positions at the University of Geneva and Firmenich, SA.
Dr. McKew currently resides on a small organic farm in the Agricultural Reserve of Montgomery County Maryland.